Prevent Hair Loss &
Promote Hair Growth
With Happy Head

Spironolactone is an FDA approved medication used to treat high blood pressure and has been used off-label for treating female pattern hair loss and adult hormonal acne. It is a testosterone blocker, preventing DHT formation. Spironolactone is typically taken once a day, and results are seen in about 6 months. More powerful than the more popular Minoxidil, which is available OTC, spironolactone is the second most commonly used medication for female pattern hair loss and is backed up by many clinical studies. In a UCLA study assessing the effectiveness of spironolactone for hair loss, 74.3% of patients receiving spironolactone reported stabilization or improvement of hair loss.¹ In another study of anti-androgen blockers that included spironolactone, 88% of female patients saw either an improvement of their female pattern hair loss or no progression of the disease. ² Since there may be side effects associated with taking oral spironolactone, Happy Head has developed an innovative topical medication that combines topical spironolactone with prescription grade minoxidil. This prescription topical medication is based on two clinical studies. In one study of topical spironolactone, 80% of patients treated with 1% topical spironolactone gel saw improvement (see photos)³. In another group where 1% topical spironolactone was combined with 5% minoxidil gel, clinical improvements were seen in 100% of the patients, with 40% of patients having excellent response, 50% having good response, and 10% of patients having fair response (see photos). In another study comparing topical finasteride to topical spironolactone, 32 patients were enrolled in the study and some of them were treated with topical spironolactone solution 5% for six months. In a patient satisfaction survey, 100% were either satisfied or very satisfied with the results. The authors concluded that “ topical finasteride and topical spironolactone are good options for management of androgenetic alopecia but topical spironolactone is better than topical finasteride with few side effects when compared to oral administration.” Spironolactone can be used simultaneously with other medications, such as birth control medications. Spironolactone is a diuretic, which means that it may help you make more urine. The most common side effects may include a change in blood pressure, such as dizziness or lightheadedness, breast tenderness, breast enlargement, irregular periods or spotting between periods. Topical application of spironolactone may have lower side effects than oral spironolactone, however side effects may still occur. Spironolactone may increase potassium levels in your body, so patients should avoid foods that are high in potassium, such as bananas, coconut water or avocados. Patients should avoid pregnancy on this medication. Spironolactone is a prescription medication, so a medical consultation is required. Happy Head includes the medical consultation for free! Efficacy of spironolactone 1% for female pattern hair loss. Photos from clinical study by Hamza Abdel-Raouf et al., a novel topical combination of minoxidil and spironolactone for androgenetic alopecia: Clinical, histopathological, and physicochemical study. ³ Efficacy of spironolactone 1% + Minoxidil 5% for hair loss. Photos from clinical study by Hamza Abdel-Raouf et al., a novel topical combination of minoxidil and spironolactone for androgenetic alopecia: Clinical, histopathological, and physicochemical study. ³